FerAppease® is an analogue of the Maternal Bovine Appeasing Substance (MBAS) for topical use in healthy cattle to help mitigate the detrimental effects of stress.

The active ingredient of FerAppease® is a synthetic analogue of the Maternal Bovine Appeasing Substance (MBAS). MBAS is naturally secreted by the sebaceous gland located on the skin of the mammary gland with the unique function of inducing an appeasing effect on the nursing offspring.

FerAppease® is topically applied and the active ingredient (MBAS) is assimilated by the vomeronasal gland located in the nose of the animals. The MBAS stimulation of the vomeronasal gland desensitizes regions of the amygdala and the hypothalamus, dramatically decreasing threat perception and its downstream stress consequences.





“Despite the fact that we gradually wean our calves, we still notice that when we move calves out of the hutches and into group housing, our calves usually “cry” for at least two days after the move. When we started using FerAppease, we noticed the calves were quiet and the social stress was gone. More importantly, dry matter intake increased and post-weaning treatments were reduced.” Scott Blevins – Dairy Manager Wiese Brothers, Greenleaf, WI.


“We are following the recommended FerAppease protocol for our baby calves. They are treated from birth

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